Fig. 1 Comparison of the syringe pumps used in the All-in-One and conventional immunoassays.
Fig. 2 Suction device of compact syringe pump.
Fig. 1 illustrates that although the shape of the syringe pump used in the All-in-One Immunoassay is different from that of conventional immunoassays, the general function of the syringe pump remains the same. The compact design of the syringe pump used in the All-in-One Immunoassay is more economical and user-friendly compared to the large pump typically used in traditional immunoassays. Moreover, the compact syringe pump is equipped with a device (depicted in Fig. 2) that can effectively suction up any residual solutions that may drip after a specific volume has been injected into the diagnostic kit, further enhancing the ease of use of the device.
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Fig. 3 Injection heads of the compact syringe pump.
The dosing capability of the compact syringe pump can be flexibly adjusted by replacing the dosing head, as demonstrated by the various types of dosing heads shown in Fig. 3.
Fig. 4 8-channel pipette operated with a compact syringe pump.
The compact syringe pump shown in Fig. 4 can be coupled with an 8- or 12-channel pipette to simultaneously inject a precise amount of sample or reagent into multiple diagnostic kits. The volume injected into each diagnostic kit using a multi-pipette ranges from 20 to 200 µL (0.02 - 0.2 mL).- or 12-channel pippete coupled with a compact syringe pump simultaneously injects a certain amount of sample or reagent into multiple diagnostic kits as shown in Fig. 4. The volume injected into each diagnostic kit using a multi pipette ranges from 20 to 200 ul (0.02 - 0.2 ml).
The company leverages the various capabilities of the compact syringe pump to design and manufacture fully automated portable and lab-based devices for All-in-One immunoassays. These devices are capable of rapidly and continuously quantifying up to 12 different antigens in a patient sample within 30 minutes, and can also quantify a target antigen from 12 different patient samples in 5 to 30 minutes. For instance, trace levels of troponin I in serum from 12 patients can be fully assayed within 10 minutes.
Equipped with racks that can hold hundreds of patient samples, the lab-based diagnostic device can deliver hundreds of test results every hour. By analyzing various antigens in bodily fluids collected from multiple patients based on the analysis schedule, this device provides rapid (<1 hour) test results that are essential for diagnosing a patient's disease.
It is worth noting that the assay time and sensitivity of any diagnostic device for an All-in-One immunoassay depends on the detection method used. The company has designed and manufactured all diagnostic devices for chemiluminescence detection since it is a more sensitive method than colorimetric, electrochemical, fluorescence, and naked-eye detections. Currently, acridinium ester, AMPPD, luminol, ODI, and TMPG chemiluminescence detections are available for the operation of diagnostic devices, while electrochemiluminescence detection systems that work with luminol or lutetium complexes will be available in the near future.
Equipped with racks that can hold hundreds of patient samples, the lab-based diagnostic device can deliver hundreds of test results every hour. By analyzing various antigens in bodily fluids collected from multiple patients based on the analysis schedule, this device provides rapid (<1 hour) test results that are essential for diagnosing a patient's disease.
It is worth noting that the assay time and sensitivity of any diagnostic device for an All-in-One immunoassay depends on the detection method used. The company has designed and manufactured all diagnostic devices for chemiluminescence detection since it is a more sensitive method than colorimetric, electrochemical, fluorescence, and naked-eye detections. Currently, acridinium ester, AMPPD, luminol, ODI, and TMPG chemiluminescence detections are available for the operation of diagnostic devices, while electrochemiluminescence detection systems that work with luminol or lutetium complexes will be available in the near future.